Precision Neuroscience

Clinical Applications

The magic of MR Spectroscopy lies in its ability to detect subtle changes in the brain’s biochemistry before structural changes occur. A proactive approach to diagnosing and monitoring neurological conditions, setting it apart from conventional MRI scans.

Brain Tumor

Magnetic Resonance Spectroscopy can aid in diagnosing and monitoring brain tumors by analyzing their chemical composition, distinguishing tumor types, tracking treatment progress, and detecting potential recurrence.

Read more about Earlier Detection of tumors using Magnetic Resonance Spectroscopy

Differentiating Radiation-Induced Necrosis from Recurrent Brain Tumor Using MR Perfusion and Spectroscopy: A Meta-Analysis

Read More using using Magnetic Resonance Spectroscopy to Determine Tumor Grade

Role of magnetic resonance spectroscopy to differentiate high-grade gliomas from metastases

Traumatic Brain Injury

MRS offers insights into the evolving biochemical changes within the injured brain, such as reduced N-acetylaspartate (NAA) levels, which reflect neuronal damage, and the presence of lactate, indicating ongoing metabolic stress. These metabolite alterations serve as critical markers, shedding light on the underlying mechanisms of TBI and guiding the development of tailored treatment strategies.

Read more about MRS in TBI

Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

Read More about the clinical utility in TBI

The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

Parkinson’s Disease

Magnetic Resonance Spectroscopy (MRS) aids tracking Parkinson’s Disease progression by quantifying metabolite changes in the substantia nigra and other relevant brain regions. It can measure alterations in metabolite concentrations, such as N-acetylaspartate (NAA) and myo-Inositol (mI), offering valuable markers for measuring disease progression.

Read more about Earlier Detection in Parkinson’s disease using Magnetic Resonance Spectroscopy

Proton Magnetic Resonance Spectroscopy for the Early Diagnosis of Parkinson Disease in the Substantia Nigra and Globus Pallidus: A Meta-Analysis With Trial Sequential Analysis

Multiple Sclerosis

MRS provides critical insights into the complex pathophysiological mechanisms underlying MS, such as elevated choline (Cho) levels indicating inflammation and decreased N-acetylaspartate (NAA) representing neuronal damage. These metabolite profiles offer invaluable markers for tracking disease evolution and guiding the adaptation of personalized treatment plans for individuals with MS.

Read more about Progression Tracking in Multiple Sclerosis using MR Spectroscopy

1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review

Alzheimer’s Disease

MRS offers crucial insights into the underlying biochemical changes associated with Alzheimer’s Disease, such as reduced N-acetylaspartate (NAA) levels indicative of neuronal loss and increased myo-Inositol (mI) pointing to neuroinflammation. These specific metabolite markers enable healthcare professionals to monitor disease advancement and tailor interventions for Alzheimer’s patients as the condition evolves.

Read more about MRS in AD

Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making

Read More about Neurometabolite changes in Alzheimer's disease progression

Meta-Analysis of Neurochemical Changes Estimated via Magnetic Resonance Spectroscopy in Mild Cognitive Impairment and Alzheimer’s Disease

Epilepsy

MRS can play a crucial role in unraveling the intricate biochemical changes occurring in the epileptic brain. Elevated lactate levels point to heightened metabolic activity during seizures, while shifts in N-acetylaspartate (NAA) concentrations may indicate neuronal dysfunction. These unique metabolite profiles serve as invaluable indicators, enabling the tracking of epilepsy’s progression and the tailoring of personalized treatment approaches for individuals living with this neurological condition.

Read more about MRS and temporal lobe epilepsy

A meta-analysis to investigate the role of magnetic resonance spectroscopy in the detection of temporal lobe epilepsy

Schizophrenia

MRS offers key insights into the intricate biochemical changes associated with schizophrenia, such as alterations in glutamate and GABA levels, providing a window into the disorder’s neurochemical underpinnings. These specific metabolite profiles serve as valuable markers for tracking the evolution of schizophrenia and informing the development of tailored treatment approaches for affected individuals.

Read more about how MRS can measure treatment efficacy in Schizophrenia -

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data

Hypoxic Ischemic Encephalopathy

MRS provides critical insights into the dynamic biochemical changes within the injured brain, such as elevated lactate and decreased N-acetylaspartate (NAA), indicating oxygen deprivation and neuronal damage, respectively. These specific metabolite profiles offer valuable markers for monitoring the evolution of HIE and guiding the customization of treatment strategies for affected individuals.

Read More about How MRS can aid in Predicting Outcomes in Hypoxic Ischemic Encephalopathy cases

Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia

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